| Date | Location | Result | |
| 02/26/22 | Sioux Falls, SD | Minnesota St. 89, Southwest Minnesota 65 | Box score |
| 02/23/22 | Marshall, MN | Southwest Minnesota 71, MSU Moorhead 67 | Box score |
| 02/19/22 | Sioux Falls, SD | Augustana (SD) 74, Southwest Minnesota 64 | Box score |
| 02/17/22 | Marshall, MN | Southwest Minnesota 72, Wayne St. (NE) 50 | Box score |
| 02/12/22 | Winona, MN | Winona St. 55, Southwest Minnesota 52 | Box score |
| 02/11/22 | Fayette, IA | Upper Iowa 68, Southwest Minnesota 51 | Box score |
| 02/05/22 | Marshall, MN | Southwest Minnesota 94, Concordia-St. Paul 85 (2OT) | Box score |
| 02/04/22 | Marshall, MN | Southwest Minnesota 63, Minnesota St. 46 | Box score |
| 01/29/22 | St. Cloud, MN | St. Cloud St. 63, Southwest Minnesota 44 | Box score |
| 01/28/22 | Duluth, MN | Minn. Duluth 65, Southwest Minnesota 49 | Box score |
| 01/22/22 | Marshall, MN | Bemidji St. 70, Southwest Minnesota 67 | Box score |
| 01/21/22 | Marshall, MN | Southwest Minnesota 63, Minn.-Crookston 55 | Box score |
| 01/14/22 | Aberdeen, SD | Northern St. 74, Southwest Minnesota 64 | Box score |
| 01/08/22 | Marshall, MN | Southwest Minnesota 70, Mary 57 | Box score |
| 01/02/22 | Marshall, MN | Sioux Falls 69, Southwest Minnesota 61 | Box score |
| 12/18/21 | Mankato, MN | Minnesota St. 96, Southwest Minnesota 74 | Box score |
| 12/17/21 | Saint Paul, MN | Concordia-St. Paul 67, Southwest Minnesota 65 | Box score |
| 12/11/21 | Marshall, MN | Southwest Minnesota 75, Upper Iowa 51 | Box score |
| 12/10/21 | Marshall, MN | Southwest Minnesota 69, Winona St. 64 | Box score |
| 12/04/21 | Marshall, MN | Southwest Minnesota 72, Augustana (SD) 58 | Box score |
| 12/02/21 | Wayne, NE | Wayne St. (NE) 69, Southwest Minnesota 65 (OT) | Box score |
| 11/23/21 | Sioux Falls, SD | Southwest Minnesota 75, Sioux Falls 67 | Box score |
| 11/20/21 | Marshall, MN | Truman 73, Southwest Minnesota 62 | Box score |
| 11/19/21 | Marshall, MN | Southwest Minnesota 79, Maryville (MO) 65 | Box score |
| 11/13/21 | Southwest Minnesota 76, Neb.-Kearney 66 | Box score | |
| 11/12/21 | Maryville, MO | Southwest Minnesota 64, Northwest Mo. St. 48 | Box score |