| Date | Location | Result | |
| 11/18/21 | Sioux Falls, SD | St. Cloud St. 3, Southwest Minnesota 0 (25-20,25-13,25-19) | Box score |
| 11/13/21 | Marshall, MN | Southwest Minnesota 3, Bemidji St. 0 (25-22,25-11,25-11) | Box score |
| 11/12/21 | Marshall, MN | Southwest Minnesota 3, Minn.-Crookston 0 (25-11,25-18,25-17) | Box score |
| 11/06/21 | St. Cloud, MN | St. Cloud St. 3, Southwest Minnesota 1 (25-17,25-21,17-25,25-17) | Box score |
| 11/05/21 | Duluth, MN | Southwest Minnesota 3, Minn. Duluth 0 (26-24,25-23,25-18) | Box score |
| 11/02/21 | Sioux Falls, SD | Augustana (SD) 3, Southwest Minnesota 1 (12-25,25-17,25-21,25-19) | Box score |
| 10/30/21 | Marshall, MN | Southwest Minnesota 3, Wayne St. (NE) 1 (18-25,25-20,25-15,25-18) | Box score |
| 10/28/21 | Sioux Falls, SD | Sioux Falls 3, Southwest Minnesota 1 (25-21,25-27,27-25,25-21) | Box score |
| 10/23/21 | Marshall, MN | Southwest Minnesota 3, Concordia-St. Paul 1 (25-22,20-25,25-18,25-11) | Box score |
| 10/22/21 | Marshall, MN | Southwest Minnesota 3, Minnesota St. 0 (25-15,25-15,25-16) | Box score |
| 10/16/21 | Fayette, IA | Upper Iowa 3, Southwest Minnesota 2 (24-26,25-20,13-25,25-19,15-13) | Box score |
| 10/15/21 | Winona, MN | Winona St. 3, Southwest Minnesota 2 (25-20,25-19,22-25,18-25,15-10) | Box score |
| 10/09/21 | Marshall, MN | Southwest Minnesota 3, Mary 0 (25-12,25-16,25-20) | Box score |
| 10/08/21 | Marshall, MN | Southwest Minnesota 3, Minot St. 0 (25-6,25-20,25-18) | Box score |
| 10/02/21 | Aberdeen, SD | Northern St. 3, Southwest Minnesota 2 (24-26,26-24,26-24,19-25,15-11) | Box score |
| 10/01/21 | Moorhead, MN | Southwest Minnesota 3, MSU Moorhead 0 (25-17,25-15,25-16) | Box score |
| 09/25/21 | Marshall, MN | Southwest Minnesota 3, Minn. Duluth 2 (25-20,25-19,20-25,22-25,15-9) | Box score |
| 09/24/21 | Marshall, MN | St. Cloud St. 3, Southwest Minnesota 0 (25-21,25-18,25-19) | Box score |
| 09/21/21 | Marshall, MN | Southwest Minnesota 3, Augustana (SD) 0 (25-20,27-25,25-16) | Box score |
| 09/18/21 | Crookston, MN | Southwest Minnesota 3, Minn.-Crookston 0 (25-13,25-17,25-12) | Box score |
| 09/17/21 | Bemidji, MN | Southwest Minnesota 3, Bemidji St. 1 (25-12,25-16,24-26,25-18) | Box score |
| 09/11/21 | Hays, KS | Southwest Minnesota 3, Adams St. 0 (25-11,25-10,25-11) | Box score |
| 09/11/21 | Hays, KS | Southwest Minnesota 3, Emporia St. 0 (25-9,25-16,25-13) | Box score |
| 09/10/21 | Hays, KS | Southwest Minnesota 3, Fort Hays St. 1 (22-25,25-20,25-21,25-22) | Box score |
| 09/10/21 | Hays, KS | Southwest Minnesota 3, Black Hills St. 0 (25-15,25-21,25-12) | Box score |
| 09/04/21 | Golden, CO | Southwest Minnesota 3, Colo. Sch. of Mines 0 (25-23,25-15,25-19) | Box score |
| 09/04/21 | Golden, CO | Southwest Minnesota 3, Colo. Christian 0 (25-15,25-19,25-22) | Box score |
| 09/03/21 | Golden, CO | Southwest Minnesota 3, Grand Valley St. 0 (25-20,25-23,27-25) | Box score |
| 09/03/21 | Golden, CO | Southwest Minnesota 3, Colorado Mesa 1 (25-27,25-18,25-23,25-21) | Box score |