| Date | Location | Result | |
| Nov 13, 2021 | Sioux Falls, South D | Augustana 55, Southwest Minnesota 0 | Box score |
| Nov 06, 2021 | Marshall, Minnesota | Minnesota State 52, Southwest Minnesota 0 | Box score |
| Oct 30, 2021 | Bemidji, Minnesota | Bemidji St. 48, Southwest Minnesota 14 | Box score |
| Oct 23, 2021 | Marshall, Minnesota | Wayne State (NE) 38, Southwest Minnesota 16 | Box score |
| Oct 16, 2021 | Winona, Minnesota | Winona St. 26, Southwest Minnesota 14 | Box score |
| Oct 09, 2021 | Marshall, Minnesota | Sioux Falls 35, Southwest Minnesota 7 | Box score |
| Oct 02, 2021 | Fayette, Iowa | Southwest Minnesota 20, Upper Iowa 14 | Box score |
| Sep 25, 2021 | St. Paul, MN | Southwest Minnesota 34, Concordia-St. Paul 24 | Box score |
| Sep 18, 2021 | Marshall, Minnesota | University of Mary 45, Southwest Minnesota 23 | Box score |
| Sep 11, 2021 | Aberdeen, South Dako | Northern State 30, Southwest Minnesota 13 | Box score |
| Sep 02, 2021 | Marshall, Minnesota | MSU Moorhead 33, Southwest Minnesota 21 | Box score |